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dc.contributor.authorOlender, Max
dc.contributor.authorAthanasiou, Lambros S.
dc.contributor.authorHernández, José M. de la Torre
dc.contributor.authorBen-Assa, Eyal
dc.contributor.authorRikhtegar Nezami, Farhad
dc.contributor.authorEdelman, Elazer R
dc.date.accessioned2020-08-14T18:30:35Z
dc.date.available2020-08-14T18:30:35Z
dc.date.issued2019-06
dc.identifier.issn1558-254X
dc.identifier.issn0278-0062
dc.identifier.urihttps://hdl.handle.net/1721.1/126586
dc.description.abstractAutomated analysis of vascular imaging techniques is limited by the inability to precisely determine arterial borders. Intravascular optical coherence tomography (OCT) offers unprecedented detail of artery wall structure and composition, but does not provide consistent visibility of the outer border of the vessel due to the limited penetration depth. Existing interpolation and surface fitting methods prove insufficient to accurately fill the gaps between the irregularly spaced and sometimes unreliably identified visible segments of the vessel outer border. This paper describes an intuitive, efficient, and flexible new method of 3D surface fitting and smoothing suitable for this task. An anisotropic linear-elastic mesh is fit to irregularly spaced and uncertain data points corresponding to visible segments of vessel borders, enabling the fully automated delineation of the entire inner and outer borders of diseased vessels in OCT images for the first time. In a clinical dataset, the proposed smooth surface fitting approach had great agreement when compared with human annotations: areas differed by just 11 ± 11% (0.93 ± 0.84 mm2), with a coefficient of determination of 0.89. Overlapping and non-overlapping area ratios were 0.91 and 0.18, respectively, with a sensitivity of 90.8 and specificity of 99.0. This spring mesh method of contour fitting significantly outperformed all alternative surface fitting and interpolation approaches tested. The application of this promising proposed method is expected to enhance clinical intervention and translational research using OCT.en_US
dc.description.sponsorshipU.S. National Institutes of Health (Grant GM 49039).en_US
dc.language.isoen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en_US
dc.relation.isversionof10.1109/TMI.2018.2884142en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleA mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography imagesen_US
dc.typeArticleen_US
dc.identifier.citationOlender, Max L. et al. "A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images." IEEE Transactions on Medical Imaging 38, 6 (June 2019): 1384-1397 ©2019 Author(s)en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering and Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.relation.journalIEEE Transactions on Medical Imagingen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2019-10-09T17:36:13Z
dspace.date.submission2019-10-09T17:36:17Z
mit.journal.volume38en_US
mit.journal.issue6en_US


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