| dc.contributor.author | Russell, M. Grace | |
| dc.contributor.author | Jamison, Timothy F | |
| dc.date.accessioned | 2020-10-23T22:03:18Z | |
| dc.date.available | 2020-10-23T22:03:18Z | |
| dc.date.issued | 2019-06 | |
| dc.date.submitted | 2019-03 | |
| dc.identifier.issn | 1433-7851 | |
| dc.identifier.issn | 1521-3773 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/128199 | |
| dc.description.abstract | Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting solvent exchanges or intermediate purification. Linezolid was obtained in 73 % isolated yield in a total residence time of 27 minutes, corresponding to a throughput of 816 mg h[superscript −1]. | en_US |
| dc.description.sponsorship | Defense Advanced Research Projects Agency (Grant N66001-16-C-4005) | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1002/anie.201901814 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | Prof. Jamison | en_US |
| dc.title | Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Russell, M. Grace and Timothy F Jamison. "Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification." Angewandte Chemie 58, 23 (June 2019): 7678-7681 | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.relation.journal | Angewandte Chemie - International Edition | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.date.submission | 2020-10-20T21:30:06Z | |
| mit.journal.volume | 58 | en_US |
| mit.journal.issue | 23 | en_US |
| mit.license | OPEN_ACCESS_POLICY | |
| mit.metadata.status | Complete | |
