Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

Author(s)
Brubaker, Douglas; Paulo, Joao A.; Sheth, Shikha; Poulin, Emily J.; Popow, Olesja; ... Show more
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Abstract
To better understand how tissue context contributes to cancer-specific signaling by the same protein, Brubaker and Paulo et al. performed mass-spectrometry-based analysis of total and phosphoproteomic datasets from four murine tissues with mutationally activated K-RAS and developed computational techniques to translate mouse signaling insights to patient tumors.
Date issued
2019-09
URI
https://hdl.handle.net/1721.1/128833
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Journal
Cell Systems
Publisher
Elsevier BV
Citation
Brubaker, Douglas K. et al. "Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation." Cell Systems 9, 3 (September 2019): 733-739 © 2019 Elsevier Inc.
Version: Author's final manuscript
ISSN
2405-4712
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