Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation
Author(s)Brubaker, Douglas; Paulo, Joao A.; Sheth, Shikha; Poulin, Emily J.; Popow, Olesja; Joughin, Brian Alan; Strasser, Samantha Dale; Starchenko, Alina; Gygi, Steven P.; Lauffenburger, Douglas A; Haigis, Kevin M.; ... Show more Show less
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To better understand how tissue context contributes to cancer-specific signaling by the same protein, Brubaker and Paulo et al. performed mass-spectrometry-based analysis of total and phosphoproteomic datasets from four murine tissues with mutationally activated K-RAS and developed computational techniques to translate mouse signaling insights to patient tumors.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Brubaker, Douglas K. et al. "Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation." Cell Systems 9, 3 (September 2019): 733-739 © 2019 Elsevier Inc.
Author's final manuscript