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Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

dc.contributor.authorBrubaker, Douglas
dc.contributor.authorPaulo, Joao A.
dc.contributor.authorSheth, Shikha
dc.contributor.authorPoulin, Emily J.
dc.contributor.authorPopow, Olesja
dc.contributor.authorJoughin, Brian Alan
dc.contributor.authorStrasser, Samantha Dale
dc.contributor.authorStarchenko, Alina
dc.contributor.authorGygi, Steven P.
dc.contributor.authorLauffenburger, Douglas A
dc.contributor.authorHaigis, Kevin M.
dc.date.accessioned2020-12-15T20:46:56Z
dc.date.available2020-12-15T20:46:56Z
dc.date.issued2019-09
dc.date.submitted2019-06
dc.identifier.issn2405-4712
dc.identifier.urihttps://hdl.handle.net/1721.1/128833
dc.description.abstractTo better understand how tissue context contributes to cancer-specific signaling by the same protein, Brubaker and Paulo et al. performed mass-spectrometry-based analysis of total and phosphoproteomic datasets from four murine tissues with mutationally activated K-RAS and developed computational techniques to translate mouse signaling insights to patient tumors.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cels.2019.07.006en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleProteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translationen_US
dc.typeArticleen_US
dc.identifier.citationBrubaker, Douglas K. et al. "Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation." Cell Systems 9, 3 (September 2019): 733-739 © 2019 Elsevier Inc.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.relation.journalCell Systemsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2020-10-19T13:47:16Z
dspace.orderedauthorsBrubaker, DK; Paulo, JA; Sheth, S; Poulin, EJ; Popow, O; Joughin, BA; Strasser, SD; Starchenko, A; Gygi, SP; Lauffenburger, DA; Haigis, KMen_US
dspace.date.submission2020-10-19T13:47:23Z
mit.journal.volume9en_US
mit.journal.issue3en_US
mit.licensePUBLISHER_CC
mit.metadata.statusComplete


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