| dc.contributor.author | Li, Guoqiang | |
| dc.contributor.author | Liu, Yaping | |
| dc.contributor.author | Zhang, Yanxiao | |
| dc.contributor.author | Kubo, Naoki | |
| dc.contributor.author | Yu, Miao | |
| dc.contributor.author | Fang, Rongxin | |
| dc.contributor.author | Kellis, Manolis | |
| dc.contributor.author | Ren, Bing | |
| dc.date.accessioned | 2021-01-12T22:56:58Z | |
| dc.date.available | 2021-01-12T22:56:58Z | |
| dc.date.issued | 2019-08 | |
| dc.date.submitted | 2018-11 | |
| dc.identifier.issn | 1548-7091 | |
| dc.identifier.issn | 1548-7105 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/129395 | |
| dc.description.abstract | We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues. | en_US |
| dc.language.iso | en | |
| dc.publisher | Springer Science and Business Media LLC | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1038/s41592-019-0502-z | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Joint profiling of DNA methylation and chromatin architecture in single cells | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Li, Guoqiang et al. "Joint profiling of DNA methylation and chromatin architecture in single cells." Nature Methods 16, 10 (August 2019): 991–993 © 2019 The Author(s) | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory | en_US |
| dc.relation.journal | Nature Methods | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2021-01-05T18:29:00Z | |
| dspace.orderedauthors | Li, G; Liu, Y; Zhang, Y; Kubo, N; Yu, M; Fang, R; Kellis, M; Ren, B | en_US |
| dspace.date.submission | 2021-01-05T18:29:04Z | |
| mit.journal.volume | 16 | en_US |
| mit.journal.issue | 10 | en_US |
| mit.license | OPEN_ACCESS_POLICY | |
| mit.metadata.status | Complete | |
