Mechano-genomic regulation of coronaviruses and its interplay with ageing

Author(s)
Uhler, Caroline; Shivashankar, G. V.
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Abstract
Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.
Date issued
2020-04
URI
https://hdl.handle.net/1721.1/130124
Department
Massachusetts Institute of Technology. Laboratory for Information and Decision Systems
Journal
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Citation
Uhler, Caroline and G. V. Shivashankar. "Mechano-genomic regulation of coronaviruses and its interplay with ageing." Nature Reviews Molecular Cell Biology 21, 5 (April 2020): 247–248. © 2020 Springer Nature Limited
Version: Author's final manuscript
ISSN
1471-0072
1471-0080
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