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Transport activity dependent regulation of the yeast general amino acid permease
(Massachusetts Institute of Technology, 2011)
The general amino acid permease Gap1p of Saccharomyces cerevisiae scavenges amino acids from the extracellular medium for use as nitrogen sources in starvation conditions. Because unlimited uptake of both naturally occurring ...
Chromatin and transcriptional regulators act in a cascade to establish a bilateral asymmetry of the C. elegans nervous system
(Massachusetts Institute of Technology, 2011)
Neuroanatomical bilateral asymmetry is a widespread feature in both vertebrates and invertebrates. Although mostly bilaterally symmetric, the nervous system of Caenorhabditis elegans displays bilateral asymmetry. Bilateral ...
Consequences of redox-active phenazines on the physiology of the opportunistic pathogen Pseudomonas aeruginosa
(Massachusetts Institute of Technology, 2013)
Phenazines are redox-active small molecules produced by bacteria. Although phenazines have been studied extensively for their roles as toxins, how phenazines benefit producing organisms is still being uncovered. Pseudomonas ...
Post-transcriptional coordination by an RNA-binding protein
(Massachusetts Institute of Technology, 2010)
RNA-binding proteins can regulate the stability, localization, and translation of their target mRNAs. Post-transcriptional regulation can orchestrate dynamic changes in gene expression, and can coordinate multiple cellular ...
Modeling the processes affecting larval haddock (Melanogrammus aeglefinus) survival on Georges Bank
(Massachusetts Institute of Technology, 2011)
The ultimate goal of early life studies of fish over the past century has been to better understand recruitment variability. Recruitment is the single most important natural event controlling year-class strength and biomass ...
Investigating the initiation and progression of small cell lung cancer
(Massachusetts Institute of Technology, 2011)
Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...
Mechanisms of substrate recognition by the AAA+ protease HslUV
(Massachusetts Institute of Technology, 2011)
Protein degradation is a central component of all biological processes. The proteome must constantly change in response to environmental stimuli. As a result, protein synthesis and regulated proteolysis are vital to cell ...
Cellular and genetic mechanisms of new tissue production in the regenerating planarian Schmidtea mediterranea
(Massachusetts Institute of Technology, 2012)
Regeneration of missing body parts is biologically fascinating, yet poorly understood. Many instances of regeneration, such as the replacement of amphibian limbs or planarian heads, require both a source for new cellular ...
Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
(Massachusetts Institute of Technology, 2010)
The classic example of experience-dependent cortical plasticity is the ocular dominance (OD) shift in visual cortex following monocular deprivation (MD). As in other mammals with binocular vision, MD in mice induces ...
Aberrant Ras/MAPK signaling in skeletal development
(Massachusetts Institute of Technology, 2013)
The Mitogen-activated protein kinase(MAPK) signaling pathway has been studied intensively in the context of neoplastic transformation. Other studies have focused on the roles of this pathway during development and have ...