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Evasion of interferon-gamma responses by Toxoplasma gondii in murine and human fibroblasts
(Massachusetts Institute of Technology, 2013)
Co-evolution of pathogen and host helps drive biological diversity. Unlike viral-host interactions, little is known about the co-evolution of eukaryotic pathogens with their hosts. The intracellular parasite Toxoplasma ...
Global analysis of the transcriptional regulation of Sinorhizobium meliloti cell cycle progression and study of cell cycle regulation during symbiosis with Medicago sativa
(Massachusetts Institute of Technology, 2013)
The complex [alpha]-proteobacterial cell cycle regulatory network is essential not only for faithful replication and segregation of the genome, but also to coordinate unique cellular differentiation events that have evolved ...
The auditory system of the minke whale (Balaenoptera acutorostrata) : a potential fatty sound reception pathway in a mysticete cetacean
(Massachusetts Institute of Technology, 2012)
Despite widespread concerns about the effects of anthropogenic noise on baleen whales (suborder Mysticeti), we lack basic information about their auditory physiology for comprehensive risk assessments. Hearing ranges and ...
Transcript leaders : annotation and insight into functions in translation
(Massachusetts Institute of Technology, 2013)
For a eukaryotic mRNA to be properly expressed, it undergoes a series of several steps, including transcription, modification, splicing, packaging, export, localization, translation, and decay. Of these steps transcription ...
Amino acid regulation of mTORC1
(Massachusetts Institute of Technology, 2013)
Mammalian target of rapamycin complex I (mTORC1) is an atypical Ser/Thr kinase that regulates cellular and organismal growth. Accordingly, mTORC1 has substantial roles in regulating insulin sensitivity and lifespan, and ...
Specificity and evolution of bacterial two-component signal transduction systems
(Massachusetts Institute of Technology, 2013)
Cells possess a remarkable capacity to sense and process a diverse range of signals. Duplication and divergence of a relatively small number of gene families has provided the raw material enabling cells to quickly increase ...
Biophysical and structural characterization of components from the nuclear pore complex and the ubiquitin pathway
(Massachusetts Institute of Technology, 2010)
Formation of an endomembrane system in the eukaryotic cell is a hallmark of biological evolution. One such system is the nuclear envelope (NE), composed of an inner and outer membrane, used to form a nucleus and enclose ...
Regulation of gene expression and cell state in embryonic stem cells
(Massachusetts Institute of Technology, 2010)
Cell state is established and maintained through the combined action of transcription factors, chromatin regulators and signaling pathways, which all contribute to a transcriptional regulatory circuitry. Embryonic stem ...
The recruitment of stromal cells to the site of tumor formation
(Massachusetts Institute of Technology, 2010)
Myofibroblasts are an alpha-smooth muscle actin ([alpha]-SMA)-expressing cell type found within human mammary carcinomas, but not in the normal mammary gland. Myofibroblasts can enhance tumor formation by promoting ...
Investigation of coiled-coil interactions between proteins of the spindle pole body
(Massachusetts Institute of Technology, 2010)
The spindle pole body (SPB) is a large multi-protein complex that organizes microtubules in yeast. Through its function of nucleating and anchoring microtubules, the SPB is essential for cell viability. High-resolution ...