Correlates of protection against SARS-CoV-2 in rhesus macaques
Author(s)McMahan, Katherine; Yu, Jingyou; Mercado, Noe B.; Loos, Carolin; Tostanoski, Lisa H.; Chandrashekar, Abishek; Liu, Jinyan; Peter, Lauren; Atyeo, Caroline; Zhu, Alex Lee; Bondzie, Esther A.; Dagotto, Gabriel; Gebre, Makda S.; Jacob-Dolan, Catherine; Li, Zhenfeng; Nampanya, Felix; Patel, Shivani; Pessaint, Laurent; Van Ry, Alex; Blade, Kelvin; Yalley-Ogunro, Jake; Cabus, Mehtap; Brown, Renita; Cook, Anthony; Teow, Elyse; Andersen, Hanne; Lewis, Mark G.; Lauffenburger, Douglas A; Alter, Galit; Barouch, Dan H.; ... Show more Show less
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Recent studies have reported the protective efficacy of both natural1 and vaccine-induced2–7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8+ T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents.
DepartmentRagon Institute of MGH, MIT and Harvard; Massachusetts Institute of Technology. Department of Biological Engineering
Springer Science and Business Media LLC
McMahan, Katherine et al. "Correlates of protection against SARS-CoV-2 in rhesus macaques." Nature 590, 7847 (December 2020): 630–634 © 2020 The Author(s).
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