dc.contributor.author | McMahan, Katherine | |
dc.contributor.author | Yu, Jingyou | |
dc.contributor.author | Mercado, Noe B. | |
dc.contributor.author | Loos, Carolin | |
dc.contributor.author | Tostanoski, Lisa H. | |
dc.contributor.author | Chandrashekar, Abishek | |
dc.contributor.author | Liu, Jinyan | |
dc.contributor.author | Peter, Lauren | |
dc.contributor.author | Atyeo, Caroline | |
dc.contributor.author | Zhu, Alex Lee | |
dc.contributor.author | Bondzie, Esther A. | |
dc.contributor.author | Dagotto, Gabriel | |
dc.contributor.author | Gebre, Makda S. | |
dc.contributor.author | Jacob-Dolan, Catherine | |
dc.contributor.author | Li, Zhenfeng | |
dc.contributor.author | Nampanya, Felix | |
dc.contributor.author | Patel, Shivani | |
dc.contributor.author | Pessaint, Laurent | |
dc.contributor.author | Van Ry, Alex | |
dc.contributor.author | Blade, Kelvin | |
dc.contributor.author | Yalley-Ogunro, Jake | |
dc.contributor.author | Cabus, Mehtap | |
dc.contributor.author | Brown, Renita | |
dc.contributor.author | Cook, Anthony | |
dc.contributor.author | Teow, Elyse | |
dc.contributor.author | Andersen, Hanne | |
dc.contributor.author | Lewis, Mark G. | |
dc.contributor.author | Lauffenburger, Douglas A | |
dc.contributor.author | Alter, Galit | |
dc.contributor.author | Barouch, Dan H. | |
dc.date.accessioned | 2021-07-21T18:31:35Z | |
dc.date.available | 2021-07-21T18:31:35Z | |
dc.date.issued | 2020-12 | |
dc.date.submitted | 2020-09 | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.issn | 1476-4687 | |
dc.identifier.uri | https://hdl.handle.net/1721.1/131122 | |
dc.description.abstract | Recent studies have reported the protective efficacy of both natural1 and vaccine-induced2–7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8+ T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents. | en_US |
dc.description.sponsorship | Bill & Melinda Gates Foundation (Grant INV-006131) | en_US |
dc.description.sponsorship | National Institutes of Health (Grants OD024917, AI129797, AI124377, AI128751, AI126603 and CA260476) | en_US |
dc.language.iso | en | |
dc.publisher | Springer Science and Business Media LLC | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/s41586-020-03041-6 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Correlates of protection against SARS-CoV-2 in rhesus macaques | en_US |
dc.type | Article | en_US |
dc.identifier.citation | McMahan, Katherine et al. "Correlates of protection against SARS-CoV-2 in rhesus macaques." Nature 590, 7847 (December 2020): 630–634 © 2020 The Author(s). | en_US |
dc.contributor.department | Ragon Institute of MGH, MIT and Harvard | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.relation.journal | Nature | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2021-07-20T13:58:38Z | |
dspace.orderedauthors | McMahan, K; Yu, J; Mercado, NB; Loos, C; Tostanoski, LH; Chandrashekar, A; Liu, J; Peter, L; Atyeo, C; Zhu, A; Bondzie, EA; Dagotto, G; Gebre, MS; Jacob-Dolan, C; Li, Z; Nampanya, F; Patel, S; Pessaint, L; Van Ry, A; Blade, K; Yalley-Ogunro, J; Cabus, M; Brown, R; Cook, A; Teow, E; Andersen, H; Lewis, MG; Lauffenburger, DA; Alter, G; Barouch, DH | en_US |
dspace.date.submission | 2021-07-20T13:58:40Z | |
mit.journal.volume | 590 | en_US |
mit.journal.issue | 7847 | en_US |
mit.license | PUBLISHER_POLICY | |
mit.metadata.status | Complete | |