Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation
Author(s)
Sivanand, Sharanya; Vander Heiden, Matthew G.
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Cancer cells must adapt metabolism to thrive despite nutrient limitations in the tumor microenvironment. In this issue of Genes & Development, King and colleagues (pp. 1345-1358) report a role for transcriptional regulators of the Hippo pathway to facilitate protein scavenging and support proliferation under some nutrient-deprived conditions.
Date issued
2020Department
Koch Institute for Integrative Cancer Research at MITJournal
Genes and Development
Publisher
Cold Spring Harbor Laboratory