An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Zhang, Huiyuan; Madi, Asaf; Yosef, Nir; Chihara, Norio; Awasthi, Amit; Pot, Caroline; Lambden, Conner; Srivastava, Amitabh; Burkett, Patrick R; Nyman, Jackson; Christian, Elena; Etminan, Yasaman; Lee, Annika; Stroh, Helene; Xia, Junrong; Karwacz, Katarzyna; Thakore, Pratiksha I; Acharya, Nandini; Schnell, Alexandra; Wang, Chao; Apetoh, Lionel; Rozenblatt-Rosen, Orit; Anderson, Ana C; Regev, Aviv; Kuchroo, Vijay K

Author(s)

Zhang, Huiyuan; Madi, Asaf; Yosef, Nir; Chihara, Norio; Awasthi, Amit; ... Show more

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Abstract

Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.

Date issued

2020

URI

https://hdl.handle.net/1721.1/134374

Department

Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT; Howard Hughes Medical Institute

Journal

Cell Reports

Publisher

Elsevier BV

Collections

MIT Open Access Articles