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An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

dc.contributor.authorZhang, Huiyuan
dc.contributor.authorMadi, Asaf
dc.contributor.authorYosef, Nir
dc.contributor.authorChihara, Norio
dc.contributor.authorAwasthi, Amit
dc.contributor.authorPot, Caroline
dc.contributor.authorLambden, Conner
dc.contributor.authorSrivastava, Amitabh
dc.contributor.authorBurkett, Patrick R
dc.contributor.authorNyman, Jackson
dc.contributor.authorChristian, Elena
dc.contributor.authorEtminan, Yasaman
dc.contributor.authorLee, Annika
dc.contributor.authorStroh, Helene
dc.contributor.authorXia, Junrong
dc.contributor.authorKarwacz, Katarzyna
dc.contributor.authorThakore, Pratiksha I
dc.contributor.authorAcharya, Nandini
dc.contributor.authorSchnell, Alexandra
dc.contributor.authorWang, Chao
dc.contributor.authorApetoh, Lionel
dc.contributor.authorRozenblatt-Rosen, Orit
dc.contributor.authorAnderson, Ana C
dc.contributor.authorRegev, Aviv
dc.contributor.authorKuchroo, Vijay K
dc.date.accessioned2021-10-27T20:04:41Z
dc.date.available2021-10-27T20:04:41Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/1721.1/134374
dc.description.abstractZhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.
dc.language.isoen
dc.publisherElsevier BV
dc.relation.isversionof10.1016/j.celrep.2020.108433
dc.rightsCreative Commons Attribution 4.0 International license
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceElsevier
dc.titleAn IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets
dc.typeArticle
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biology
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MIT
dc.contributor.departmentHoward Hughes Medical Institute
dc.relation.journalCell Reports
dc.eprint.versionFinal published version
dc.type.urihttp://purl.org/eprint/type/JournalArticle
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.date.updated2021-07-22T16:15:10Z
dspace.orderedauthorsZhang, H; Madi, A; Yosef, N; Chihara, N; Awasthi, A; Pot, C; Lambden, C; Srivastava, A; Burkett, PR; Nyman, J; Christian, E; Etminan, Y; Lee, A; Stroh, H; Xia, J; Karwacz, K; Thakore, PI; Acharya, N; Schnell, A; Wang, C; Apetoh, L; Rozenblatt-Rosen, O; Anderson, AC; Regev, A; Kuchroo, VK
dspace.date.submission2021-07-22T16:15:13Z
mit.journal.volume33
mit.journal.issue8
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Needed


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