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This is not the latest version of this item. The latest version can be found at:https://dspace.mit.edu/handle/1721.1/134407.2
Are redox changes a critical switch for mitotic progression?
| dc.contributor.author | Lim, Daniel C | |
| dc.contributor.author | Joukov, Vladimir | |
| dc.contributor.author | Yaffe, Michael B | |
| dc.date.accessioned | 2021-10-27T20:04:52Z | |
| dc.date.available | 2021-10-27T20:04:52Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/134407 | |
| dc.description.abstract | © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy. | |
| dc.language.iso | en | |
| dc.publisher | Informa UK Limited | |
| dc.relation.isversionof | 10.1080/23723556.2020.1832419 | |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Taylor & Francis | |
| dc.title | Are redox changes a critical switch for mitotic progression? | |
| dc.type | Article | |
| dc.relation.journal | Molecular and Cellular Oncology | |
| dc.eprint.version | Final published version | |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | |
| dc.date.updated | 2021-08-04T15:14:02Z | |
| dspace.orderedauthors | Lim, DC; Joukov, V; Yaffe, MB | |
| dspace.date.submission | 2021-08-04T15:14:03Z | |
| mit.journal.volume | 7 | |
| mit.journal.issue | 6 | |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Authority Work and Publication Information Needed |
