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Are redox changes a critical switch for mitotic progression?

Author(s)
Lim, Daniel C; Joukov, Vladimir; Yaffe, Michael B
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Abstract
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.
Date issued
2020
URI
https://hdl.handle.net/1721.1/134407
Journal
Molecular and Cellular Oncology
Publisher
Informa UK Limited
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21721.1/134407.22021-11-30T15:37:46ZAuthority information verified/added.
11721.1/134407*2021-10-27T20:04:52Z

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