Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

Author(s)
Sheppard, Hadley E; Dall’Agnese, Alessandra; Park, Woojun D; Shamim, M Hamza; Dubrulle, Julien; ... Show more
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Abstract
© 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy.
Date issued
2021
URI
https://hdl.handle.net/1721.1/134416
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Cell Reports Medicine
Publisher
Elsevier BV
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