| dc.contributor.author | Sheppard, Hadley E | |
| dc.contributor.author | Dall’Agnese, Alessandra | |
| dc.contributor.author | Park, Woojun D | |
| dc.contributor.author | Shamim, M Hamza | |
| dc.contributor.author | Dubrulle, Julien | |
| dc.contributor.author | Johnson, Hannah L | |
| dc.contributor.author | Stossi, Fabio | |
| dc.contributor.author | Cogswell, Patricia | |
| dc.contributor.author | Sommer, Josh | |
| dc.contributor.author | Levy, Joan | |
| dc.contributor.author | Sharifnia, Tanaz | |
| dc.contributor.author | Wawer, Mathias J | |
| dc.contributor.author | Nabet, Behnam | |
| dc.contributor.author | Gray, Nathanael S | |
| dc.contributor.author | Clemons, Paul A | |
| dc.contributor.author | Schreiber, Stuart L | |
| dc.contributor.author | Workman, Paul | |
| dc.contributor.author | Young, Richard A | |
| dc.contributor.author | Lin, Charles Y | |
| dc.date.accessioned | 2021-10-27T20:04:55Z | |
| dc.date.available | 2021-10-27T20:04:55Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/134416 | |
| dc.description.abstract | © 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective transcriptional regulator of chordoma identity, and they confirm that brachyury targeting is a promising therapeutic strategy. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier BV | |
| dc.relation.isversionof | 10.1016/j.xcrm.2020.100188 | |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Elsevier | |
| dc.title | Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity | |
| dc.type | Article | |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | |
| dc.contributor.department | Whitehead Institute for Biomedical Research | |
| dc.relation.journal | Cell Reports Medicine | |
| dc.eprint.version | Final published version | |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | |
| dc.date.updated | 2021-08-04T18:39:08Z | |
| dspace.orderedauthors | Sheppard, HE; Dall’Agnese, A; Park, WD; Shamim, MH; Dubrulle, J; Johnson, HL; Stossi, F; Cogswell, P; Sommer, J; Levy, J; Sharifnia, T; Wawer, MJ; Nabet, B; Gray, NS; Clemons, PA; Schreiber, SL; Workman, P; Young, RA; Lin, CY | |
| dspace.date.submission | 2021-08-04T18:39:13Z | |
| mit.journal.volume | 2 | |
| mit.journal.issue | 1 | |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Authority Work and Publication Information Needed | |
