RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

Author(s)
Wesselhoeft, R Alexander; Kowalski, Piotr S; Parker-Hale, Frances C; Huang, Yuxuan; Bisaria, Namita; ... Show more
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Abstract
© 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.
Date issued
2019
URI
https://hdl.handle.net/1721.1/135094
Department
Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Political Science; Whitehead Institute for Biomedical Research; Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Harvard University--MIT Division of Health Sciences and Technology
Journal
Molecular Cell
Publisher
Elsevier BV
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