GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models
Name
1-s2.0-S2211124719316808-main.pdf
Description
Published version
Size
2.98 MB
Format
Adobe PDF
Checksum (MD5)
737e662dfde95eec5151d656604f79be
Author(s)
Hanson, Jesse E
Ma, Keran
Elstrott, Justin
Weber, Martin
Saillet, Sandrine
Khan, Abdullah S
Simms, Jeffrey
Liu, Benjamin
Kim, Thomas A
Yu, Gui-Qiu
Date Issued
2020
Journal
Cell Reports
Publisher
Elsevier BV
Version
Final published version
Abstract
Hanson et al. examine the therapeutic effects of enhancing GluN2A-subunit-containing NMDAR function in Dravet syndrome and Alzheimer's disease mice. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in both disease models. GluN2A NMDAR enhancers may benefit brain disorders with network hypersynchrony and cognitive impairments.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELREP.2019.12.030
