GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models

Author(s)
Hanson, Jesse E; Ma, Keran; Elstrott, Justin; Weber, Martin; Saillet, Sandrine; ... Show more
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Abstract
Hanson et al. examine the therapeutic effects of enhancing GluN2A-subunit-containing NMDAR function in Dravet syndrome and Alzheimer's disease mice. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in both disease models. GluN2A NMDAR enhancers may benefit brain disorders with network hypersynchrony and cognitive impairments.
Date issued
2020
URI
https://hdl.handle.net/1721.1/135208
Department
Picower Institute for Learning and Memory; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal
Cell Reports
Publisher
Elsevier BV
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