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GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models

dc.contributor.authorHanson, Jesse E
dc.contributor.authorMa, Keran
dc.contributor.authorElstrott, Justin
dc.contributor.authorWeber, Martin
dc.contributor.authorSaillet, Sandrine
dc.contributor.authorKhan, Abdullah S
dc.contributor.authorSimms, Jeffrey
dc.contributor.authorLiu, Benjamin
dc.contributor.authorKim, Thomas A
dc.contributor.authorYu, Gui-Qiu
dc.contributor.authorChen, Yelin
dc.contributor.authorWang, Tzu-Ming
dc.contributor.authorJiang, Zhiyu
dc.contributor.authorLiederer, Bianca M
dc.contributor.authorDeshmukh, Gauri
dc.contributor.authorSolanoy, Hilda
dc.contributor.authorChan, Connie
dc.contributor.authorSellers, Benjamin D
dc.contributor.authorVolgraf, Matthew
dc.contributor.authorSchwarz, Jacob B
dc.contributor.authorHackos, David H
dc.contributor.authorWeimer, Robby M
dc.contributor.authorSheng, Morgan
dc.contributor.authorGill, T Michael
dc.contributor.authorScearce-Levie, Kimberly
dc.contributor.authorPalop, Jorge J
dc.date.accessioned2021-10-27T20:22:28Z
dc.date.available2021-10-27T20:22:28Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/1721.1/135208
dc.description.abstractHanson et al. examine the therapeutic effects of enhancing GluN2A-subunit-containing NMDAR function in Dravet syndrome and Alzheimer's disease mice. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in both disease models. GluN2A NMDAR enhancers may benefit brain disorders with network hypersynchrony and cognitive impairments.
dc.language.isoen
dc.publisherElsevier BV
dc.relation.isversionof10.1016/J.CELREP.2019.12.030
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs License
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceElsevier
dc.titleGluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models
dc.typeArticle
dc.contributor.departmentPicower Institute for Learning and Memory
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.relation.journalCell Reports
dc.eprint.versionFinal published version
dc.type.urihttp://purl.org/eprint/type/JournalArticle
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.date.updated2021-03-23T18:13:49Z
dspace.orderedauthorsHanson, JE; Ma, K; Elstrott, J; Weber, M; Saillet, S; Khan, AS; Simms, J; Liu, B; Kim, TA; Yu, G-Q; Chen, Y; Wang, T-M; Jiang, Z; Liederer, BM; Deshmukh, G; Solanoy, H; Chan, C; Sellers, BD; Volgraf, M; Schwarz, JB; Hackos, DH; Weimer, RM; Sheng, M; Gill, TM; Scearce-Levie, K; Palop, JJ
dspace.date.submission2021-03-23T18:13:51Z
mit.journal.volume30
mit.journal.issue2
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Needed


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