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Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo
| dc.contributor.author | Leboeuf, Dominique | |
| dc.contributor.author | Abakumova, Tatiana | |
| dc.contributor.author | Prikazchikova, Tatiana | |
| dc.contributor.author | Rhym, Luke | |
| dc.contributor.author | Anderson, Daniel G | |
| dc.contributor.author | Zatsepin, Timofei S | |
| dc.contributor.author | Piatkov, Konstantin I | |
| dc.date.accessioned | 2021-10-27T20:34:47Z | |
| dc.date.available | 2021-10-27T20:34:47Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/136300 | |
| dc.description.abstract | © 2020 The American Society of Gene and Cell Therapy With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the Arg/N-degron pathway in a murine hepatocellular carcinoma model, Leboeuf et al. demonstrated potentiated action of chemotherapy. Since components of this pathway are ubiquitously expressed, targeting the N-degron pathway has the potential to increase effectiveness of therapy in many cancer types. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier BV | |
| dc.relation.isversionof | 10.1016/J.YMTHE.2020.01.021 | |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.source | Elsevier | |
| dc.title | Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo | |
| dc.type | Article | |
| dc.relation.journal | Molecular Therapy | |
| dc.eprint.version | Final published version | |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | |
| dc.date.updated | 2021-06-03T17:33:36Z | |
| dspace.orderedauthors | Leboeuf, D; Abakumova, T; Prikazchikova, T; Rhym, L; Anderson, DG; Zatsepin, TS; Piatkov, KI | |
| dspace.date.submission | 2021-06-03T17:33:38Z | |
| mit.journal.volume | 28 | |
| mit.journal.issue | 4 | |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Authority Work and Publication Information Needed |
