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Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo
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© 2020 The American Society of Gene and Cell Therapy With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the Arg/N-degron pathway in a murine hepatocellular carcinoma model, Leboeuf et al. demonstrated potentiated action of chemotherapy. Since components of this pathway are ubiquitously expressed, targeting the N-degron pathway has the potential to increase effectiveness of therapy in many cancer types.
Date issued
2020Journal
Molecular Therapy
Publisher
Elsevier BV