The Ups and Downs of the Striatum: Dopamine Biases Upstate Balance of Striosomes and Matrix
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© 2020 Elsevier Inc. Prager et al. demonstrate an opposite regulation of activity in striosomes and matrix of the striatum. By a D1-receptor-linked L-VGCC-dependent mechanism, dopamine release can extend upstates in matrix D1-expressing projection neurons (dSPNs) but shorten them in striosomal dSPNs.
Date issued
2020Department
McGovern Institute for Brain Research at MIT; Massachusetts Institute of Technology. Department of Brain and Cognitive SciencesJournal
Neuron
Publisher
Elsevier BV
Citation
Graybiel, Ann M and Matsushima, Ayano. 2020. "The Ups and Downs of the Striatum: Dopamine Biases Upstate Balance of Striosomes and Matrix." Neuron, 108 (6).
Version: Author's final manuscript