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A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2
| dc.contributor.author | Gopalsamuthiram, Vijayagopal | |
| dc.contributor.author | Williams, Corshai | |
| dc.contributor.author | Noble, Jeffrey | |
| dc.contributor.author | Jamison, Tim | |
| dc.contributor.author | Gupton, B Frank | |
| dc.contributor.author | Snead, David R | |
| dc.date.accessioned | 2022-03-09T15:52:32Z | |
| dc.date.available | 2022-03-09T15:52:32Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/141086 | |
| dc.description.abstract | © 2021 Georg Thieme Verlag. All rights reserved. A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance. | en_US |
| dc.language.iso | en | |
| dc.publisher | Georg Thieme Verlag KG | en_US |
| dc.relation.isversionof | 10.1055/A-1275-2848 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | chemRxiv | en_US |
| dc.title | A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2 | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Gopalsamuthiram, Vijayagopal, Williams, Corshai, Noble, Jeffrey, Jamison, Tim, Gupton, B Frank et al. 2021. "A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2." Synlett, 32 (03). | |
| dc.relation.journal | Synlett | en_US |
| dc.eprint.version | Original manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/NonPeerReviewed | en_US |
| dc.date.updated | 2022-03-09T15:48:02Z | |
| dspace.orderedauthors | Gopalsamuthiram, V; Williams, C; Noble, J; Jamison, T; Gupton, BF; Snead, DR | en_US |
| dspace.date.submission | 2022-03-09T15:48:03Z | |
| mit.journal.volume | 32 | en_US |
| mit.journal.issue | 03 | en_US |
| mit.license | OPEN_ACCESS_POLICY | |
| mit.metadata.status | Authority Work and Publication Information Needed | en_US |
