Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube
Author(s)
Fame, Ryann M.; Cortés‐Campos, Christian; Sive, Hazel L.
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Alternative title
A Primer with Latest Insights
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© 2020 WILEY Periodicals, Inc. The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid (CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube is a hallmark of the chordate CNS, and a closed neural tube is essential for normal development. Development and function of the ventricular system is examined, emphasizing three interdigitating components that form a functional system: ventricle walls, CSF fluid properties, and activity of CSF constituent factors. The cellular lining of the ventricle both can produce and is responsive to CSF. Fluid properties and conserved CSF components contribute to normal CNS development. Anomalies of the CSF/ventricular system serve as diagnostics and may cause CNS disorders, further highlighting their importance. This review focuses on the evolution and development of the brain ventricular system, associated function, and connected pathologies. It is geared as an introduction for scholars with little background in the field.
Date issued
2020-02Department
Whitehead Institute for Biomedical Research; Massachusetts Institute of Technology. Department of BiologyJournal
BioEssays
Publisher
Wiley
Citation
Fame, Ryann M, Cortés-Campos, Christian and Sive, Hazel L. 2020. "Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube: A Primer with Latest Insights." BioEssays, 42 (3).
Version: Final published version
ISSN
0265-9247
1521-1878