Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

Author(s)
Zhivaki, Dania; Borriello, Francesco; Chow, Ohn A; Doran, Benjamin; Fleming, Ira; ... Show more
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Abstract
© 2020 The Author(s) Inflammasome activation in dendritic cells (DCs) leads to pyroptosis or hyperactivation. Zhivaki et al. show that in contrast to pyroptotic DCs, hyperactive DCs stimulate durable anti-tumor immunity that eradicates established tumors. These protective responses are intrinsic to cDC1 cells and depend on DC hypermigration and on the inflammasome-dependent cytokine IL-1β.
Date issued
2020
URI
https://hdl.handle.net/1721.1/141288
Department
Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Koch Institute for Integrative Cancer Research at MIT; Ragon Institute of MGH, MIT and Harvard
Journal
Cell Reports
Publisher
Elsevier BV
Citation
Zhivaki, Dania, Borriello, Francesco, Chow, Ohn A, Doran, Benjamin, Fleming, Ira et al. 2020. "Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity." Cell Reports, 33 (7).
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