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Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

dc.contributor.authorZhivaki, Dania
dc.contributor.authorBorriello, Francesco
dc.contributor.authorChow, Ohn A
dc.contributor.authorDoran, Benjamin
dc.contributor.authorFleming, Ira
dc.contributor.authorTheisen, Derek J
dc.contributor.authorPallis, Paris
dc.contributor.authorShalek, Alex K
dc.contributor.authorSokol, Caroline L
dc.contributor.authorZanoni, Ivan
dc.contributor.authorKagan, Jonathan C
dc.date.accessioned2022-03-18T14:51:01Z
dc.date.available2022-03-18T14:51:01Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/1721.1/141288
dc.description.abstract© 2020 The Author(s) Inflammasome activation in dendritic cells (DCs) leads to pyroptosis or hyperactivation. Zhivaki et al. show that in contrast to pyroptotic DCs, hyperactive DCs stimulate durable anti-tumor immunity that eradicates established tumors. These protective responses are intrinsic to cDC1 cells and depend on DC hypermigration and on the inflammasome-dependent cytokine IL-1β.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/J.CELREP.2020.108381en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceElsevieren_US
dc.titleInflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunityen_US
dc.typeArticleen_US
dc.identifier.citationZhivaki, Dania, Borriello, Francesco, Chow, Ohn A, Doran, Benjamin, Fleming, Ira et al. 2020. "Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity." Cell Reports, 33 (7).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistry
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Science
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MIT
dc.contributor.departmentRagon Institute of MGH, MIT and Harvard
dc.relation.journalCell Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2022-03-18T14:34:54Z
dspace.orderedauthorsZhivaki, D; Borriello, F; Chow, OA; Doran, B; Fleming, I; Theisen, DJ; Pallis, P; Shalek, AK; Sokol, CL; Zanoni, I; Kagan, JCen_US
dspace.date.submission2022-03-18T14:34:56Z
mit.journal.volume33en_US
mit.journal.issue7en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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