MIT Libraries homeMIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation

Author(s)
Gregurec, Danijela; Senko, Alexander W; Chuvilin, Andrey; Reddy, Pooja D; Sankararaman, Ashwin; Rosenfeld, Dekel; Chiang, Po-Han; Garcia, Francisco; Tafel, Ian; Varnavides, Georgios; Ciocan, Eugenia; Anikeeva, Polina; ... Show more Show less
Thumbnail
DownloadAccepted version (1.107Mb)
Open Access Policy

Open Access Policy

Creative Commons Attribution-Noncommercial-Share Alike

Terms of use
Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/
Metadata
Show full item record
Abstract
© 2020 American Chemical Society. Magnetic nanomaterials in magnetic fields can serve as versatile transducers for remote interrogation of cell functions. In this study, we leveraged the transition from vortex to in-plane magnetization in iron oxide nanodiscs to modulate the activity of mechanosensory cells. When a vortex configuration of spins is present in magnetic nanomaterials, it enables rapid control over their magnetization direction and magnitude. The vortex configuration manifests in near zero net magnetic moment in the absence of a magnetic field, affording greater colloidal stability of magnetic nanomaterials in suspensions. Together, these properties invite the application of magnetic vortex particles as transducers of externally applied minimally invasive magnetic stimuli in biological systems. Using magnetic modeling and electron holography, we predict and experimentally demonstrate magnetic vortex states in an array of colloidally synthesized magnetite nanodiscs 98-226 nm in diameter. The magnetic nanodiscs applied as transducers of torque for remote control of mechanosensory neurons demonstrated the ability to trigger Ca2+ influx in weak (≤28 mT), slowly varying (≤5 Hz) magnetic fields. The extent of cellular response was determined by the magnetic nanodisc volume and magnetic field conditions. Magnetomechanical activation of a mechanosensitive cation channel TRPV4 (transient receptor potential vanilloid family member 4) exogenously expressed in the nonmechanosensitive HEK293 cells corroborated that the stimulation is mediated by mechanosensitive ion channels. With their large magnetic torques and colloidal stability, magnetic vortex particles may facilitate basic studies of mechanoreception and its applications to control electroactive cells with remote magnetic stimuli.
Date issued
2020
URI
https://hdl.handle.net/1721.1/142479
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Gregurec, Danijela, Senko, Alexander W, Chuvilin, Andrey, Reddy, Pooja D, Sankararaman, Ashwin et al. 2020. "Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation." ACS Nano, 14 (7).
Version: Author's final manuscript

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries homeMIT Libraries logo

Find us on

Twitter Facebook Instagram YouTube RSS

MIT Libraries navigation

SearchHours & locationsBorrow & requestResearch supportAbout us
PrivacyPermissionsAccessibility
MIT
Massachusetts Institute of Technology
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.