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dc.contributor.authorGregurec, Danijela
dc.contributor.authorSenko, Alexander W
dc.contributor.authorChuvilin, Andrey
dc.contributor.authorReddy, Pooja D
dc.contributor.authorSankararaman, Ashwin
dc.contributor.authorRosenfeld, Dekel
dc.contributor.authorChiang, Po-Han
dc.contributor.authorGarcia, Francisco
dc.contributor.authorTafel, Ian
dc.contributor.authorVarnavides, Georgios
dc.contributor.authorCiocan, Eugenia
dc.contributor.authorAnikeeva, Polina
dc.date.accessioned2022-05-11T16:44:17Z
dc.date.available2022-05-11T16:44:17Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/1721.1/142479
dc.description.abstract© 2020 American Chemical Society. Magnetic nanomaterials in magnetic fields can serve as versatile transducers for remote interrogation of cell functions. In this study, we leveraged the transition from vortex to in-plane magnetization in iron oxide nanodiscs to modulate the activity of mechanosensory cells. When a vortex configuration of spins is present in magnetic nanomaterials, it enables rapid control over their magnetization direction and magnitude. The vortex configuration manifests in near zero net magnetic moment in the absence of a magnetic field, affording greater colloidal stability of magnetic nanomaterials in suspensions. Together, these properties invite the application of magnetic vortex particles as transducers of externally applied minimally invasive magnetic stimuli in biological systems. Using magnetic modeling and electron holography, we predict and experimentally demonstrate magnetic vortex states in an array of colloidally synthesized magnetite nanodiscs 98-226 nm in diameter. The magnetic nanodiscs applied as transducers of torque for remote control of mechanosensory neurons demonstrated the ability to trigger Ca2+ influx in weak (≤28 mT), slowly varying (≤5 Hz) magnetic fields. The extent of cellular response was determined by the magnetic nanodisc volume and magnetic field conditions. Magnetomechanical activation of a mechanosensitive cation channel TRPV4 (transient receptor potential vanilloid family member 4) exogenously expressed in the nonmechanosensitive HEK293 cells corroborated that the stimulation is mediated by mechanosensitive ion channels. With their large magnetic torques and colloidal stability, magnetic vortex particles may facilitate basic studies of mechanoreception and its applications to control electroactive cells with remote magnetic stimuli.en_US
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionof10.1021/ACSNANO.0C00562en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 Internationalen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleMagnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulationen_US
dc.typeArticleen_US
dc.identifier.citationGregurec, Danijela, Senko, Alexander W, Chuvilin, Andrey, Reddy, Pooja D, Sankararaman, Ashwin et al. 2020. "Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation." ACS Nano, 14 (7).
dc.relation.journalACS Nanoen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2022-05-11T16:39:14Z
dspace.orderedauthorsGregurec, D; Senko, AW; Chuvilin, A; Reddy, PD; Sankararaman, A; Rosenfeld, D; Chiang, P-H; Garcia, F; Tafel, I; Varnavides, G; Ciocan, E; Anikeeva, Pen_US
dspace.date.submission2022-05-11T16:39:16Z
mit.journal.volume14en_US
mit.journal.issue7en_US
mit.licenseOPEN_ACCESS_POLICY
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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