Evolution towards Virulence in a Burkholderia Two-Component System

Author(s)
Schaefers, Matthew M; Wang, Benjamin X; Boisvert, Nicole M; Martini, Sarah J; Bonney, Sarah L; ... Show more
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Abstract
<jats:p> Infections caused by members of the <jats:named-content content-type="genus-species">Burkholderia cepacia</jats:named-content> complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with BCC, mutations in genes encoding the FixLJ system often become prevalent, suggesting that these changes may benefit the bacteria during infection. </jats:p>
Date issued
2021
URI
https://hdl.handle.net/1721.1/146863
Department
Massachusetts Institute of Technology. Department of Biology
Journal
mBio
Publisher
American Society for Microbiology
Citation
Schaefers, Matthew M, Wang, Benjamin X, Boisvert, Nicole M, Martini, Sarah J, Bonney, Sarah L et al. 2021. "Evolution towards Virulence in a Burkholderia Two-Component System." mBio, 12 (4).
Version: Final published version
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