A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

Author(s)
Shahsavari, Negar; Wang, Boyuan; Imai, Yu; Mori, Miho; Son, Sangkeun; ... Show more
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Abstract
<jats:p> Drug-resistant Gram-negative bacteria have become the major problem driving the antimicrobial resistance crisis. Searching outside the overmined actinomycetes, we focused on <jats:italic>Photorhabdus</jats:italic> , gut symbionts of enthomopathogenic nematodes that carry up to 40 biosynthetic gene clusters coding for secondary metabolites. </jats:p>
Date issued
2022
URI
https://hdl.handle.net/1721.1/146865
Department
Massachusetts Institute of Technology. Department of Biology
Journal
mBio
Publisher
American Society for Microbiology
Citation
Shahsavari, Negar, Wang, Boyuan, Imai, Yu, Mori, Miho, Son, Sangkeun et al. 2022. "A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP." mBio, 13 (3).
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