Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?
Name
nihms-1720151.pdf
Description
Accepted version
Size
46.31 KB
Format
Adobe PDF
Checksum (MD5)
d8efcbc122e7571c41c3e7038384dcea
Author(s)
Nabel, Christopher S
Vander Heiden, Matthew G
Date Issued
2021
Journal
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Citation
Nabel, Christopher S and Vander Heiden, Matthew G. 2021. "Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?." Cancer Research, 81 (17).
Version
Author's final manuscript
Abstract
Abstract
A major goal of cancer research is to understand the requirements for cancer growth and progression that can be exploited to treat patients. Model systems reduce the complexity and heterogeneity of human cancers to explore therapeutic hypotheses, however, some relevant aspects of human biology are not well represented by certain models, complicating the translation of preclinical findings to help patients. Here we discuss the advantages and limitations of patient-derived xenografts as a model system to study cancer metabolism, offering a framework to best use these models to address different types of metabolism-specific research questions.
A major goal of cancer research is to understand the requirements for cancer growth and progression that can be exploited to treat patients. Model systems reduce the complexity and heterogeneity of human cancers to explore therapeutic hypotheses, however, some relevant aspects of human biology are not well represented by certain models, complicating the translation of preclinical findings to help patients. Here we discuss the advantages and limitations of patient-derived xenografts as a model system to study cancer metabolism, offering a framework to best use these models to address different types of metabolism-specific research questions.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1158/0008-5472.CAN-21-0770
