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dc.contributor.authorNabel, Christopher S
dc.contributor.authorVander Heiden, Matthew G
dc.date.accessioned2023-01-09T17:41:20Z
dc.date.available2023-01-09T17:41:20Z
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/1721.1/147018
dc.description.abstract<jats:title>Abstract</jats:title> <jats:p>A major goal of cancer research is to understand the requirements for cancer growth and progression that can be exploited to treat patients. Model systems reduce the complexity and heterogeneity of human cancers to explore therapeutic hypotheses, however, some relevant aspects of human biology are not well represented by certain models, complicating the translation of preclinical findings to help patients. Here we discuss the advantages and limitations of patient-derived xenografts as a model system to study cancer metabolism, offering a framework to best use these models to address different types of metabolism-specific research questions.</jats:p>en_US
dc.language.isoen
dc.publisherAmerican Association for Cancer Research (AACR)en_US
dc.relation.isversionof10.1158/0008-5472.CAN-21-0770en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titlePatient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?en_US
dc.typeArticleen_US
dc.identifier.citationNabel, Christopher S and Vander Heiden, Matthew G. 2021. "Patient-Derived Xenografts to Study Cancer Metabolism: When Does X Mark the Spot?." Cancer Research, 81 (17).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.relation.journalCancer Researchen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-01-09T17:30:18Z
dspace.orderedauthorsNabel, CS; Vander Heiden, MGen_US
dspace.date.submission2023-01-09T17:30:19Z
mit.journal.volume81en_US
mit.journal.issue17en_US
mit.licenseOPEN_ACCESS_POLICY
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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