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The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia

dc.contributor.authorWang, Chuangqi
dc.contributor.authorLi, Yijia
dc.contributor.authorKaplonek, Paulina
dc.contributor.authorGentili, Matteo
dc.contributor.authorFischinger, Stephanie
dc.contributor.authorBowman, Kathryn A
dc.contributor.authorSade-Feldman, Moshe
dc.contributor.authorKays, Kyle R
dc.contributor.authorRegan, James
dc.contributor.authorFlynn, James P
dc.contributor.authorGoldberg, Marcia B
dc.contributor.authorHacohen, Nir
dc.contributor.authorFilbin, Michael R
dc.contributor.authorLauffenburger, Douglas A
dc.contributor.authorAlter, Galit
dc.contributor.authorLi, Jonathan Z
dc.date.accessioned2023-02-03T16:51:50Z
dc.date.available2023-02-03T16:51:50Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/1721.1/147856
dc.description.abstract<jats:p>We showed that persistent SARS-CoV-2 RNAemia is an independent predictor of severe COVID-19. We observed that SARS-CoV-2-targeted antibody maturation, specifically Fc-effector functions rather than neutralization, was strongly linked with the ability to rapidly clear viremia.</jats:p>en_US
dc.language.isoen
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.isversionof10.1128/MBIO.01577-22en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourcemBioen_US
dc.titleThe Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemiaen_US
dc.typeArticleen_US
dc.identifier.citationWang, Chuangqi, Li, Yijia, Kaplonek, Paulina, Gentili, Matteo, Fischinger, Stephanie et al. 2022. "The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia." mBio, 13 (4).
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.relation.journalmBioen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-02-03T16:35:18Z
dspace.orderedauthorsWang, C; Li, Y; Kaplonek, P; Gentili, M; Fischinger, S; Bowman, KA; Sade-Feldman, M; Kays, KR; Regan, J; Flynn, JP; Goldberg, MB; Hacohen, N; Filbin, MR; Lauffenburger, DA; Alter, G; Li, JZen_US
dspace.date.submission2023-02-03T16:35:22Z
mit.journal.volume13en_US
mit.journal.issue4en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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