Role of MUC5B during Group B Streptococcal Vaginal Colonization

Author(s)
Burcham, Lindsey R; Bath, Jade R; Werlang, Caroline A; Lyon, Laurie M; Liu, Naoko; ... Show more
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Abstract
<jats:p> Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B <jats:named-content content-type="genus-species">Streptococcus</jats:named-content> (GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can ascend to the uterus to cause preterm birth and fetal infection <jats:italic>in utero.</jats:italic> Here we show that a prominent mucin found in the FRT, MUC5B, promotes host defense by inhibiting GBS interaction with epithelial cells found in the FRT and ascension from the vagina to the uterus <jats:italic>in vivo</jats:italic> . </jats:p>
Date issued
2022
URI
https://hdl.handle.net/1721.1/147917
Department
Massachusetts Institute of Technology. Department of Biological Engineering
Journal
mBio
Publisher
American Society for Microbiology
Citation
Burcham, Lindsey R, Bath, Jade R, Werlang, Caroline A, Lyon, Laurie M, Liu, Naoko et al. 2022. "Role of MUC5B during Group B Streptococcal Vaginal Colonization." mBio, 13 (2).
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