| dc.contributor.author | Burcham, Lindsey R | |
| dc.contributor.author | Bath, Jade R | |
| dc.contributor.author | Werlang, Caroline A | |
| dc.contributor.author | Lyon, Laurie M | |
| dc.contributor.author | Liu, Naoko | |
| dc.contributor.author | Evans, Christopher | |
| dc.contributor.author | Ribbeck, Katharina | |
| dc.contributor.author | Doran, Kelly S | |
| dc.date.accessioned | 2023-02-06T19:17:03Z | |
| dc.date.available | 2023-02-06T19:17:03Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/147917 | |
| dc.description.abstract | <jats:p>
Mucin glycoproteins are a major component that contributes to the complexity of the female reproductive tract (FRT). Group B
<jats:named-content content-type="genus-species">Streptococcus</jats:named-content>
(GBS) is present in the FRT of 25–30% of healthy women, but during pregnancy can ascend to the uterus to cause preterm birth and fetal infection
<jats:italic>in utero.</jats:italic>
Here we show that a prominent mucin found in the FRT, MUC5B, promotes host defense by inhibiting GBS interaction with epithelial cells found in the FRT and ascension from the vagina to the uterus
<jats:italic>in vivo</jats:italic>
.
</jats:p> | en_US |
| dc.language.iso | en | |
| dc.publisher | American Society for Microbiology | en_US |
| dc.relation.isversionof | 10.1128/MBIO.00039-22 | en_US |
| dc.rights | Creative Commons Attribution 4.0 International license | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | mBio | en_US |
| dc.title | Role of MUC5B during Group B Streptococcal Vaginal Colonization | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Burcham, Lindsey R, Bath, Jade R, Werlang, Caroline A, Lyon, Laurie M, Liu, Naoko et al. 2022. "Role of MUC5B during Group B Streptococcal Vaginal Colonization." mBio, 13 (2). | |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.relation.journal | mBio | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2023-02-06T19:08:06Z | |
| dspace.orderedauthors | Burcham, LR; Bath, JR; Werlang, CA; Lyon, LM; Liu, N; Evans, C; Ribbeck, K; Doran, KS | en_US |
| dspace.date.submission | 2023-02-06T19:08:08Z | |
| mit.journal.volume | 13 | en_US |
| mit.journal.issue | 2 | en_US |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Authority Work and Publication Information Needed | en_US |
