Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

Author(s)
Rochman, Nash D; Faure, Guilhem; Wolf, Yuri I; Freddolino, Peter L; Zhang, Feng; ... Show more
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Abstract
<jats:p>Emergence of vaccine escape variants of SARS-CoV-2 is arguably the most pressing problem during the COVID-19 pandemic as vaccines are distributed worldwide. We employed a computational approach to assess the risk of antibody escape resulting from mutations in the receptor-binding domain of the spike protein of the wild-type SARS-CoV-2 virus as well as the Delta, Gamma, and Omicron variants.</jats:p>
Date issued
2022-04-26
URI
https://hdl.handle.net/1721.1/150406
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Journal
mBio
Publisher
American Society for Microbiology
Citation
Rochman, Nash D, Faure, Guilhem, Wolf, Yuri I, Freddolino, Peter L, Zhang, Feng et al. 2022. "Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape." mBio, 13 (2).
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