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dc.contributor.authorBloom, Paul A.
dc.contributor.authorPagliaccio, David
dc.contributor.authorZhang, Jiahe
dc.contributor.authorBauer, Clemens C. C.
dc.contributor.authorKyler, Mia
dc.contributor.authorGreene, Keara D.
dc.contributor.authorTreves, Isaac
dc.contributor.authorMorfini, Francesca
dc.contributor.authorDurham, Katherine
dc.contributor.authorCherner, Rachel
dc.contributor.authorBajwa, Zia
dc.contributor.authorWool, Emma
dc.contributor.authorOlafsson, Valur
dc.contributor.authorLee, Ray F.
dc.date.accessioned2023-10-24T14:47:26Z
dc.date.available2023-10-24T14:47:26Z
dc.date.issued2023-10-17
dc.identifier.urihttps://hdl.handle.net/1721.1/152519
dc.description.abstractAbstract Background Adolescence is characterized by a heightened vulnerability for Major Depressive Disorder (MDD) onset, and currently, treatments are only effective for roughly half of adolescents with MDD. Accordingly, novel interventions are urgently needed. This study aims to establish mindfulness-based real-time fMRI neurofeedback (mbNF) as a non-invasive approach to downregulate the default mode network (DMN) in order to decrease ruminatory processes and depressive symptoms. Methods Adolescents (N = 90) with a current diagnosis of MDD ages 13–18-years-old will be randomized in a parallel group, two-arm, superiority trial to receive either 15 or 30 min of mbNF with a 1:1 allocation ratio. Real-time neurofeedback based on activation of the frontoparietal network (FPN) relative to the DMN will be displayed to participants via the movement of a ball on a computer screen while participants practice mindfulness in the scanner. We hypothesize that within-DMN (medial prefrontal cortex [mPFC] with posterior cingulate cortex [PCC]) functional connectivity will be reduced following mbNF (Aim 1: Target Engagement). Additionally, we hypothesize that participants in the 30-min mbNF condition will show greater reductions in within-DMN functional connectivity (Aim 2: Dosing Impact on Target Engagement). Aim 1 will analyze data from all participants as a single-group, and Aim 2 will leverage the randomized assignment to analyze data as a parallel-group trial. Secondary analyses will probe changes in depressive symptoms and rumination. Discussion Results of this study will determine whether mbNF reduces functional connectivity within the DMN among adolescents with MDD, and critically, will identify the optimal dosing with respect to DMN modulation as well as reduction in depressive symptoms and rumination. Trial Registration This study has been registered with clinicaltrials.gov, most recently updated on July 6, 2023 (trial identifier: NCT05617495).en_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofhttps://doi.org/10.1186/s12888-023-05223-8en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleMindfulness-based real-time fMRI neurofeedback: a randomized controlled trial to optimize dosing for depressed adolescentsen_US
dc.typeArticleen_US
dc.identifier.citationBMC Psychiatry. 2023 Oct 17;23(1):757en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.identifier.mitlicensePUBLISHER_CC
dc.identifier.mitlicensePUBLISHER_CC
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-10-22T03:14:50Z
dc.language.rfc3066en
dc.rights.holderBioMed Central Ltd., part of Springer Nature
dspace.embargo.termsN
dspace.date.submission2023-10-22T03:14:50Z
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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