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dc.contributor.authorFlores, Pamela
dc.contributor.authorMcBride, Samantha A.
dc.contributor.authorGalazka, Jonathan M.
dc.contributor.authorVaranasi, Kripa K.
dc.contributor.authorZea, Luis
dc.date.accessioned2024-05-10T21:00:32Z
dc.date.available2024-05-10T21:00:32Z
dc.date.issued2023-08-16
dc.identifier.issn2373-8065
dc.identifier.urihttps://hdl.handle.net/1721.1/154925
dc.description.abstractThe undesirable, yet inevitable, presence of bacterial biofilms in spacecraft poses a risk to the proper functioning of systems and to astronauts’ health. To mitigate the risks that arise from them, it is important to understand biofilms’ behavior in microgravity. As part of the Space Biofilms project, biofilms of <jats:italic>Pseudomonas aeruginosa</jats:italic> were grown in spaceflight over material surfaces. Stainless Steel 316 (SS316) and passivated SS316 were tested for their relevance as spaceflight hardware components, while a lubricant impregnated surface (LIS) was tested as potential biofilm control strategy. The morphology and gene expression of biofilms were characterized. Biofilms in microgravity are less robust than on Earth. LIS strongly inhibits biofilm formation compared to SS. Furthermore, this effect is even greater in spaceflight than on Earth, making LIS a promising option for spacecraft use. Transcriptomic profiles for the different conditions are presented, and potential mechanisms of biofilm reduction on LIS are discussed.en_US
dc.language.isoen
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.isversionof10.1038/s41526-023-00316-wen_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceSpringer Science and Business Media LLCen_US
dc.titleBiofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfacesen_US
dc.typeArticleen_US
dc.identifier.citationFlores, P., McBride, S.A., Galazka, J.M. et al. Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces. npj Microgravity 9, 66 (2023).en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineering
dc.relation.journalnpj Microgravityen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2024-05-10T20:56:57Z
dspace.orderedauthorsFlores, P; McBride, SA; Galazka, JM; Varanasi, KK; Zea, Len_US
dspace.date.submission2024-05-10T20:56:59Z
mit.journal.volume9en_US
mit.journal.issue1en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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