Browsing MIT Open Access Articles by Author "Eaton, Elinor Ng"
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Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells
Kröger, Cornelia; Afeyan, Alexander; Mraz, Jasmin; Eaton, Elinor Ng; Reinhardt, Ferenc; e.a. (Proceedings of the National Academy of Sciences, 2019-04)Carcinoma cells residing in an intermediate phenotypic state along the epithelial–mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as invasiveness, tumor-initiating ability, and metastatic ... -
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Kojima, Yasushi; Acar, Ahmet; Eaton, Elinor Ng; Mellody, Kieran T.; Scheel, Christina; e.a. (National Academy of Sciences (U.S.), 2010-11)Much interest is currently focused on the emerging role of tumor-stroma interactions essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast ... -
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
Clauser, Karl R.; Fröse, Julia; Ye, Xin; Eaton, Elinor Ng; Reinhardt, Ferenc; e.a. (Springer Nature, 2014-09)The cell-biological program termed the epithelial-mesenchymal transition (EMT) confers on cancer cells mesenchymal traits and an ability to enter the cancer stem cell (CSC) state. However, the interactions between CSCs and ... -
Direct and Indirect Regulators of Epithelial–Mesenchymal Transition–Mediated Immunosuppression in Breast Carcinomas
Dongre, Anushka; Rashidian, Mohammad; Eaton, Elinor Ng; Reinhardt, Ferenc; Thiru, Prathapan; e.a. (American Association for Cancer Research (AACR), 2021)The epithelial-to-mesenchymal transition, which conveys epithelial (E) carcinoma cells to quasi-mesenchymal (qM) states, enables them to metastasize and acquire resistance to certain treatments. Murine tumors composed of ... -
Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
Scheel, Christina; Eaton, Elinor Ng; Chaffer, Christine L.; Reinhardt, Ferenc; Kah, Kong-Jie; e.a. (Elsevier, 2011-06)The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of motility, invasiveness, and self-renewal traits. During both normal development and tumor pathogenesis, this change in cell phenotype ...