Browsing MIT Open Access Articles by Title
Now showing items 165-184 of 55846
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3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice
(Springer Science and Business Media LLC, 2019)© 2019, The Author(s). Alzheimer’s disease (AD) is a progressive, neurodegenerative dementia with no cure. Prominent hypotheses suggest accumulation of beta-amyloid (Aβ) contributes to neurodegeneration and memory loss, ... -
3D MAS NMR Experiment Utilizing Through-Space
(American Chemical Society (ACS), 2017-05)We demonstrate a novel 3D NNC magic angle spinning NMR experiment that generates ¹⁵N–¹⁵N internuclear contacts in protein systems using an optimized ¹⁵N–¹⁵N proton assisted recoupling (PAR) mixing period and a ¹³C dimension ... -
3D matrix‐embedding inhibits cycloheximide‐mediated sensitization to TNF‐alpha‐induced apoptosis of human endothelial cells
(Wiley, 2017-11)The programmed form of cell death (apoptosis) is essential for normal development of multicellular organisms. Dysregulation of apoptosis has been linked with embryonal death and is involved in the pathophysiology of various ... -
3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
(Royal Society of Chemistry (RSC), 2018-09)Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed, several micro- devices are being developed specifically for clinical use to test novel cancer therapeutics. To be effective, ... -
A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines
(Springer Nature, 2018)© 2018, The Author(s). Hypoxia is a common feature of the tumor microenvironment. Accumulating evidence has demonstrated hypoxia to be an important trigger of tumor cell invasion or metastasizes via hypoxia-signaling ... -
A 3D model of ovarian cancer cell lines on peptide nanofiber scaffold to explore the cell–scaffold interaction and chemotherapeutic resistance of anticancer drugs
(Dove Medical Press, 2011-02)RADA16-I peptide hydrogel, a type of nanofiber scaffold derived from self-assembling peptide RADA16-I, has been extensively applied to regenerative medicine and tissue repair in order to develop novel nanomedicine systems. ... -
3D Modeling with Silhouettes
(Association for Computing Machinery (ACM), 2010-07)We present a new sketch-based modeling approach in which models are interactively designed by drawing their 2D silhouettes from different views. The core idea of our paper is to limit the input to 2D silhouettes, removing ... -
3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model
(Elsevier, 2015-05)Background & Aims Liver biopsy, the gold standard for assessing liver fibrosis, suffers from limitations due to sampling error and invasiveness. There is therefore a critical need for methods to non-invasively quantify ... -
3D nanofabrication by volumetric deposition and controlled shrinkage of patterned scaffolds
(American Association for the Advancement of Science (AAAS), 2018-12)Lithographic nanofabrication is often limited to successive fabrication of two-dimensional (2D) layers. We present a strategy for the direct assembly of 3D nanomaterials consisting of metals, semiconductors, and biomolecules ... -
3D optical imagery for motion compensation in a limb ultrasound system
(SPIE, 2016-02)Conventional processes for prosthetic socket fabrication are heavily subjective, often resulting in an interface to the human body that is neither comfortable nor completely functional. With nearly 100% of amputees reporting ... -
3D pose estimation and segmentation using specular cues
(Institute of Electrical and Electronics Engineers, 2009-08)We present a system for fast model-based segmentation and 3D pose estimation of specular objects using appearance based specular features. We use observed (a) specular reflection and (b) specular flow as cues, which are ... -
3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators
(Springer Science and Business Media LLC, 2021-06)Background: In response to supply shortages caused by the COVID-19 pandemic, N95 filtering facepiece respirators (FFRs or “masks”), which are typically single-use devices in healthcare settings, are routinely being used ... -
3D Printed Multimaterial Microfluidic Valve
(Public Library of Science, 2016-08)We present a novel 3D printed multimaterial microfluidic proportional valve. The microfluidic valve is a fundamental primitive that enables the development of programmable, automated devices for controlling fluids in a ... -
3D printed multiplexed electrospinning sources for large-scale production of aligned nanofiber mats with small diameter spread
(IOP Publishing, 2017-09)We report the design, fabrication, and characterization of novel, low-cost, and modular miniaturized nanofiber electrospinning sources for the scalable production of non-woven aligned nanofiber mats with low diameter ... -
3D printed structures for modeling the Young’s modulus of bamboo parenchyma
(Elsevier BV, 2018-03)Bamboo is a sustainable, lightweight material that is widely used in structural applications. To fully develop micromechanical models for plants, such as bamboo, the mechanical properties of each individual type of tissue ... -
3D printing metals like thermoplastics: Fused filament fabrication of metallic glasses
(Elsevier, 2018-12-04)Whereas 3D printing of thermoplastics is highly advanced and can readily create complex geometries, 3D printing of metals is still challenging and limited. The origin of this asymmetry in technological maturity is the ... -
3D printing of conducting polymers
(Springer Science and Business Media LLC, 2020)© 2020, The Author(s). Conducting polymers are promising material candidates in diverse applications including energy storage, flexible electronics, and bioelectronics. However, the fabrication of conducting polymers has ... -
3D Printing Variable Stiffness Foams Using Viscous Thread Instability
(Nature Publishing Group, 2016-08)Additive manufacturing of cellular structures has numerous applications ranging from fabrication of biological scaffolds and medical implants, to mechanical weight reduction and control over mechanical properties. Various ...
