Wide-field extended-resolution fluorescence microscopy with standing surface plasmon resonance waves
Author(s)Kim, Yang-Hyo; Tang, Wai Teng; So, Peter T. C.; Chung, Euiheon; Sheppard, Colin J. R.
Wide-field extended-resolution fluorescence microscopy with standing surface-plasmon-resonance waves
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The resolution of conventional SPR imaging has been limited by the diffraction nature of light. A wide-field extended-resolution optical imaging technique, standing-wave surface plasmon resonance fluorescence (SW-SPRF) microscopy, has been developed. Based on evanescent SPR standing waves, SW-SPRF provides lateral resolution approaching 100 nm and offers the advantages of significant signal enhancement and background noise reduction. SW-SPRF has the potential for sensitive biomolecular detection, nanoscale imaging, and lithographic applications.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Optical Society of America
Euiheon Chung, Yang-Hyo Kim, Wai Teng Tang, Colin J. R. Sheppard, and Peter T. C. So, "Wide-field extended-resolution fluorescence microscopy with standing surface-plasmon-resonance waves," Opt. Lett. 34, 2366-2368 (2009)
Author's final manuscript