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Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Author(s)
Hunter, David J.; Peltonen, Leena; Guiducci, Candace; Crawford, Gabriel; Hirschhorn, Joel N.; Lyon, Helen N.; Speliotes, Elizabeth K.; ... Show more Show less
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Abstract
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×10[superscript −11]) and MSRA (WC, P = 8.9×10[superscript −9]). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10[superscript −8]). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
Date issued
2009-06
URI
http://hdl.handle.net/1721.1/52570
Department
Broad Institute of MIT and Harvard
Journal
PLoS Genetics
Publisher
Public Library of Science
Citation
Lindgren, Cecilia M. et al. “Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.” PLoS Genet 5.6 (2009): e1000508.
Version: Final published version
ISSN
1553-7404
1553-7390

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