| dc.contributor.author | Hunter, David J. | |
| dc.contributor.author | Peltonen, Leena | |
| dc.contributor.author | Guiducci, Candace | |
| dc.contributor.author | Crawford, Gabriel | |
| dc.contributor.author | Hirschhorn, Joel N. | |
| dc.contributor.author | Lyon, Helen N. | |
| dc.contributor.author | Speliotes, Elizabeth K. | |
| dc.date.accessioned | 2010-03-15T13:12:35Z | |
| dc.date.available | 2010-03-15T13:12:35Z | |
| dc.date.issued | 2009-06 | |
| dc.date.submitted | 2009-02 | |
| dc.identifier.issn | 1553-7404 | |
| dc.identifier.issn | 1553-7390 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/52570 | |
| dc.description.abstract | To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×10[superscript −11]) and MSRA (WC, P = 8.9×10[superscript −9]). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10[superscript −8]). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity. | en |
| dc.description.sponsorship | Vandervell Foundation and Wellcome Trust (068545/Z/02, GR072960, GR076113, GR069224, 086596/Z/08/Z) | en |
| dc.description.sponsorship | University of Oxford | en |
| dc.description.sponsorship | UK Department of Health Policy Research Programme | en |
| dc.description.sponsorship | UK National Institute of Health Research | en |
| dc.description.sponsorship | Swedish Medical Research Council (8691) | en |
| dc.description.sponsorship | Swedish Heart-Lung Foundation | en |
| dc.description.sponsorship | Support for Science Funding (UK) | en |
| dc.description.sponsorship | Stockholm County Council (560183) | en |
| dc.description.sponsorship | Scottish Executive Chief Scientist's Office | en |
| dc.description.sponsorship | Peninsula Medical School | en |
| dc.description.sponsorship | Novartis | en |
| dc.description.sponsorship | Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) (050-060-810) | en |
| dc.description.sponsorship | Netherlands Center of Medical Systems Biology | en |
| dc.description.sponsorship | Netherlands Organization for Scientific Research | en |
| dc.description.sponsorship | National Human Genome Research Institute (HG02651) | en |
| dc.description.sponsorship | National Institute of Diabetes and Digestive and Kidney Diseases (DK062370; DK072193; DK075787; DK079466; DK080145; DK067288; DK07191) | en |
| dc.description.sponsorship | National Heart, Lung and Blood Institute (HL087679 [STAMPEED], HL084729) | en |
| dc.description.sponsorship | National Institute on Aging | en |
| dc.description.sponsorship | National Institutes of Health (US: intramural programs (1Z01-HG000024) | en |
| dc.description.sponsorship | Munich Center of Health Sciences | en |
| dc.description.sponsorship | MedStar Research Institute | en |
| dc.description.sponsorship | Medical Research Council UK (G0000934, G0000649, G0601261, G0500539, G9521010D, G0600705) | en |
| dc.description.sponsorship | Knut and Alice Wallenberg Foundation | en |
| dc.description.sponsorship | Kings College London | en |
| dc.description.sponsorship | Karolinska Institute | en |
| dc.description.sponsorship | Sigrid Juselius Foundation | en |
| dc.description.sponsorship | GlaxoSmithKline | en |
| dc.description.sponsorship | German National Genome Research Net | en |
| dc.description.sponsorship | Folkhälsan Research Foundation | en |
| dc.description.sponsorship | Finnish Cultural Foundation | en |
| dc.description.sponsorship | Finnish Heart Association | en |
| dc.description.sponsorship | Swiss National Science Foundation (Grant 33CSCO-122661) | en |
| dc.description.sponsorship | Faculty of Biology and Medicine of Lausanne, Switzerland | en |
| dc.description.sponsorship | European Commission (Framework VI: LSHG-CT-2004-518153 [EURODIA]; LSHG-CT-2004-512066 [MolPAGE]; LSHM-CT-2006-037197; LSHM-CT-2003-503041; QL46-CT-2002-02629 [GENOMOS]; LSHM-CT-2007-037273; Framework VII: HEALTH-F4-2007- 201413 [ENGAGE]) | en |
| dc.description.sponsorship | Diabetes UK | en |
| dc.description.sponsorship | Cancer Research UK, CIDR (NIH Contract Number N01-HG-65403) | en |
| dc.description.sponsorship | Camstrad | en |
| dc.description.sponsorship | British Heart Foundation | en |
| dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (UK) | en |
| dc.description.sponsorship | Biocentrum Helsinki | en |
| dc.description.sponsorship | The Barts and The London Charity | en |
| dc.description.sponsorship | AstraZeneca AB | en |
| dc.description.sponsorship | Arthritis Research Campaign | en |
| dc.description.sponsorship | American Diabetes Association | en |
| dc.description.sponsorship | ADA Smith Family Foundation Pinnacle Program | en |
| dc.description.sponsorship | Academy of Finland (104781, 124243) | en |
| dc.language.iso | en_US | |
| dc.publisher | Public Library of Science | en |
| dc.relation.isversionof | http://dx.doi.org/10.1371/journal.pgen.1000508 | en |
| dc.rights | Creative Commons Attribution | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/2.5/ | en |
| dc.source | PLoS | en |
| dc.title | Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution | en |
| dc.type | Article | en |
| dc.identifier.citation | Lindgren, Cecilia M. et al. “Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.” PLoS Genet 5.6 (2009): e1000508. | en |
| dc.contributor.department | Broad Institute of MIT and Harvard | en_US |
| dc.contributor.approver | Peltonen, Leena | |
| dc.contributor.mitauthor | Hunter, David J. | |
| dc.contributor.mitauthor | Peltonen, Leena | |
| dc.contributor.mitauthor | Guiducci, Candace | |
| dc.contributor.mitauthor | Crawford, Gabriel | |
| dc.contributor.mitauthor | Hirschhorn, Joel N. | |
| dc.contributor.mitauthor | Lyon, Helen N. | |
| dc.contributor.mitauthor | Speliotes, Elizabeth K. | |
| dc.relation.journal | PLoS Genetics | en |
| dc.eprint.version | Final published version | en |
| dc.identifier.pmid | 19557161 | |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en |
| dspace.orderedauthors | Lindgren, Cecilia M.; Heid, Iris M.; Randall, Joshua C.; Lamina, Claudia; Steinthorsdottir, Valgerdur; Qi, Lu; Speliotes, Elizabeth K.; Thorleifsson, Gudmar; Willer, Cristen J.; Herrera, Blanca M.; Jackson, Anne U.; Lim, Noha; Scheet, Paul; Soranzo, Nicole; Amin, Najaf; Aulchenko, Yurii S.; Chambers, John C.; Drong, Alexander; Luan, Jian'an; Lyon, Helen N.; Rivadeneira, Fernando; Sanna, Serena; Timpson, Nicholas J.; Zillikens, M. Carola; Zhao, Jing Hua; Almgren, Peter; Bandinelli, Stefania; Bennett, Amanda J.; Bergman, Richard N.; Bonnycastle, Lori L.; Bumpstead, Suzannah J.; Chanock, Stephen J.; Cherkas, Lynn; Chines, Peter; Coin, Lachlan; Cooper, Cyrus; Crawford, Gabriel; Doering, Angela; Dominiczak, Anna; Doney, Alex S. F.; Ebrahim, Shah; Elliott, Paul; Erdos, Michael R.; Estrada, Karol; Ferrucci, Luigi; Fischer, Guido; Forouhi, Nita G.; Gieger, Christian; Grallert, Harald; Groves, Christopher J.; Grundy, Scott; Guiducci, Candace; Hadley, David; Hamsten, Anders; Havulinna, Aki S.; Hofman, Albert; Holle, Rolf; Holloway, John W.; Illig, Thomas; Isomaa, Bo; Jacobs, Leonie C.; Jameson, Karen; Jousilahti, Pekka; Karpe, Fredrik; Kuusisto, Johanna; Laitinen, Jaana; Lathrop, G. Mark; Lawlor, Debbie A.; Mangino, Massimo; McArdle, Wendy L.; Meitinger, Thomas; Morken, Mario A.; Morris, Andrew P.; Munroe, Patricia; Narisu, Narisu; Nordström, Anna; Nordström, Peter; Oostra, Ben A.; Palmer, Colin N. A.; Payne, Felicity; Peden, John F.; Prokopenko, Inga; Renström, Frida; Ruokonen, Aimo; Salomaa, Veikko; Sandhu, Manjinder S.; Scott, Laura J.; Scuteri, Angelo; Silander, Kaisa; Song, Kijoung; Yuan, Xin; Stringham, Heather M.; Swift, Amy J.; Tuomi, Tiinamaija; Uda, Manuela; Vollenweider, Peter; Waeber, Gerard; Wallace, Chris; Walters, G. Bragi; Weedon, Michael N.; Witteman, Jacqueline C. M.; Zhang, Cuilin; Zhang, Weihua; Caulfield, Mark J.; Collins, Francis S.; Davey Smith, George; Day, Ian N. M.; Franks, Paul W.; Hattersley, Andrew T.; Hu, Frank B.; Jarvelin, Marjo-Riitta; Kong, Augustine; Kooner, Jaspal S.; Laakso, Markku; Lakatta, Edward; Mooser, Vincent; Morris, Andrew D.; Peltonen, Leena; Samani, Nilesh J.; Spector, Timothy D.; Strachan, David P.; Tanaka, Toshiko; Tuomilehto, Jaakko; Uitterlinden, André G.; van Duijn, Cornelia M.; Wareham, Nicholas J.; Watkins for the PROCARDIS consortia, Hugh; Waterworth, Dawn M.; Boehnke, Michael; Deloukas, Panos; Groop, Leif; Hunter, David J.; Thorsteinsdottir, Unnur; Schlessinger, David; Wichmann, H.-Erich; Frayling, Timothy M.; Abecasis, Gonçalo R.; Hirschhorn, Joel N.; Loos, Ruth J. F.; Stefansson, Kari; Mohlke, Karen L.; Barroso, Inês; McCarthy for the GIANT consortium, Mark I. | en |
| mit.license | PUBLISHER_CC | en |
| mit.metadata.status | Complete | |
