Microfluidic in vivo screen identifies compounds enhancing neuronal
Author(s)Haggarty, Stephen J.; Norton, Stephanie; Samara, Chrysanthi; Gilleland, Cody Lee; Rohde, Christopher Benjamin; Yanik, Mehmet Fatih; ... Show more Show less
Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration
MetadataShow full item record
Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens for compounds enhancing neuronal regeneration. These screens are enabled by the microfluidic devices we have developed for C. elegans. The devices enable rapid and repeatable animal immobilization which allows high-throughput and precise surgery. Following surgery, animals are exposed to the contents of a small-molecule library and assayed for neuronal regeneration. Using this screening method we have identified several compounds that enhance neural regeneration in vivo.
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Research Laboratory of Electronics
Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009. EMBC 2009.
Institute of Electrical and Electronics Engineers
Rohde, C.B. et al. “Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration.” Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE. 2009. 5950-5952. © 2009 Institute of Electrical and Electronics Engineers
Final published version
INSPEC Accession Number: 10984060