Show simple item record

Microfluidic in vivo screen identifies compounds enhancing neuronal

dc.contributor.authorHaggarty, Stephen J.
dc.contributor.authorNorton, Stephanie
dc.contributor.authorSamara, Chrysanthi
dc.contributor.authorGilleland, Cody Lee
dc.contributor.authorRohde, Christopher Benjamin
dc.contributor.authorYanik, Mehmet Fatih
dc.date.accessioned2010-04-02T19:50:14Z
dc.date.available2010-04-02T19:50:14Z
dc.date.issued2009-11
dc.date.submitted2009-09
dc.identifier.isbn978-1-4244-3296-7
dc.identifier.issn1557-170X
dc.identifier.otherINSPEC Accession Number: 10984060
dc.identifier.urihttp://hdl.handle.net/1721.1/53513
dc.description.abstractCompound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens for compounds enhancing neuronal regeneration. These screens are enabled by the microfluidic devices we have developed for C. elegans. The devices enable rapid and repeatable animal immobilization which allows high-throughput and precise surgery. Following surgery, animals are exposed to the contents of a small-molecule library and assayed for neuronal regeneration. Using this screening method we have identified several compounds that enhance neural regeneration in vivo.en
dc.description.sponsorshipNIH Director's New Innovator Award Program (1-DP2-OD002989-01)en
dc.language.isoen_US
dc.publisherInstitute of Electrical and Electronics Engineersen
dc.relation.isversionofhttp://dx.doi.org/10.1109/IEMBS.2009.5334771en
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en
dc.sourceIEEEen
dc.titleMicrofluidic in vivo screen identifies compounds enhancing neuronalen
dc.title.alternativeMicrofluidic in vivo screen identifies compounds enhancing neuronal regenerationen
dc.typeArticleen
dc.identifier.citationRohde, C.B. et al. “Microfluidic in vivo screen identifies compounds enhancing neuronal regeneration.” Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE. 2009. 5950-5952. © 2009 Institute of Electrical and Electronics Engineersen
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.approverYanik, Mehmet Fatih
dc.contributor.mitauthorSamara, Chrysanthi
dc.contributor.mitauthorGilleland, Cody Lee
dc.contributor.mitauthorRohde, Christopher Benjamin
dc.contributor.mitauthorYanik, Mehmet Fatih
dc.relation.journalAnnual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009. EMBC 2009.en
dc.eprint.versionFinal published versionen
dc.type.urihttp://purl.org/eprint/type/ConferencePaperen
eprint.statushttp://purl.org/eprint/status/PeerRevieweden
dspace.orderedauthorsRohde, Christopher B.; Gilleland, Cody; Samara, Chrysanthi; Norton, Stephanie; Haggarty, Stephen; Yanik, Mehmet Fatihen
dc.identifier.orcidhttps://orcid.org/0000-0002-4612-1962
mit.licensePUBLISHER_POLICYen
mit.metadata.statusComplete


Files in this item

Thumbnail
Name:
Rohde-2009-Microfluidic in vivo.pdf
Size:
791.7Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record