Tissue-Specific Activities of SARM-ASK1-MKK3 Signaling Coordinate Immunity and Behavior to Pathogenic and Nutritional Bacteria in C. elegans
Author(s)
Kim, Dennis H.; Pagano, Daniel Joseph; Kooistra, Tristan G.; Chu, Stephanie W.; Shivers, Robert P.
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Alternative title
Tissue-Specific Activities of an Immune Signaling Module Regulate Physiological Responses to Pathogenic and Nutritional Bacteria in C. elegans
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Microbes represent both an essential source of nutrition and a potential source of lethal infection to the nematode Caenorhabditis elegans. Immunity in C. elegans requires a signaling module comprised of orthologs of the mammalian Toll-interleukin-1 receptor (TIR) domain protein SARM, the mitogen-activated protein kinase kinase kinase (MAPKKK) ASK1, and MAPKK MKK3, which activates p38 MAPK. We determined that the SARM-ASK1-MKK3 module has dual tissue-specific roles in the C. elegans response to pathogens—in the cell-autonomous regulation of innate immunity and the neuroendocrine regulation of serotonin-dependent aversive behavior. SARM-ASK1-MKK3 signaling in the sensory nervous system also regulates egg-laying behavior that is dependent on bacteria provided as a nutrient source. Our data demonstrate that these physiological responses to bacteria share a common mechanism of signaling through the SARM-ASK1-MKK3 module and suggest the co-option of ancestral immune signaling pathways in the evolution of physiological responses to microbial pathogens and nutrients.
Date issued
2009-10Department
Massachusetts Institute of Technology. Department of BiologyJournal
Cell Host and Microbe
Publisher
Cell Press
Citation
Shivers, Robert P. et al. “Tissue-Specific Activities of an Immune Signaling Module Regulate Physiological Responses to Pathogenic and Nutritional Bacteria in C. elegans.” Cell Host & Microbe 6.4 (2009): 321-330.
Version: Author's final manuscript
ISSN
1931-3128
Keywords
Microbio, Molimmuno