dc.contributor.author | Kim, Dennis H. | |
dc.contributor.author | Pagano, Daniel Joseph | |
dc.contributor.author | Kooistra, Tristan G. | |
dc.contributor.author | Chu, Stephanie W. | |
dc.contributor.author | Shivers, Robert P. | |
dc.date.accessioned | 2010-07-15T15:52:30Z | |
dc.date.available | 2010-07-15T15:52:30Z | |
dc.date.issued | 2009-10 | |
dc.date.submitted | 2009-06 | |
dc.identifier.issn | 1931-3128 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/56561 | |
dc.description.abstract | Microbes represent both an essential source of nutrition and a potential source of lethal infection to the nematode Caenorhabditis elegans. Immunity in C. elegans requires a signaling module comprised of orthologs of the mammalian Toll-interleukin-1 receptor (TIR) domain protein SARM, the mitogen-activated protein kinase kinase kinase (MAPKKK) ASK1, and MAPKK MKK3, which activates p38 MAPK. We determined that the SARM-ASK1-MKK3 module has dual tissue-specific roles in the C. elegans response to pathogens—in the cell-autonomous regulation of innate immunity and the neuroendocrine regulation of serotonin-dependent aversive behavior. SARM-ASK1-MKK3 signaling in the sensory nervous system also regulates egg-laying behavior that is dependent on bacteria provided as a nutrient source. Our data demonstrate that these physiological responses to bacteria share a common mechanism of signaling through the SARM-ASK1-MKK3 module and suggest the co-option of ancestral immune signaling pathways in the evolution of physiological responses to microbial pathogens and nutrients. | en_US |
dc.description.sponsorship | United States National Institutes of Health (GM084477) | en_US |
dc.description.sponsorship | Burroughs Wellcome Fund | en_US |
dc.language.iso | en_US | |
dc.publisher | Cell Press | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1016/j.chom.2009.09.001 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Dennis Kim | en_US |
dc.subject | Microbio | en_US |
dc.subject | Molimmuno | en_US |
dc.title | Tissue-Specific Activities of SARM-ASK1-MKK3 Signaling Coordinate Immunity and Behavior to Pathogenic and Nutritional Bacteria in C. elegans | en_US |
dc.title.alternative | Tissue-Specific Activities of an Immune Signaling Module Regulate Physiological Responses to Pathogenic and Nutritional Bacteria in C. elegans | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Shivers, Robert P. et al. “Tissue-Specific Activities of an Immune Signaling Module Regulate Physiological Responses to Pathogenic and Nutritional Bacteria in C. elegans.” Cell Host & Microbe 6.4 (2009): 321-330. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.approver | Kim, Dennis H. | |
dc.contributor.mitauthor | Kim, Dennis H. | |
dc.contributor.mitauthor | Pagano, Daniel Joseph | |
dc.contributor.mitauthor | Kooistra, Tristan G. | |
dc.contributor.mitauthor | Chu, Stephanie W. | |
dc.contributor.mitauthor | Shivers, Robert P. | |
dc.relation.journal | Cell Host and Microbe | en_US |
dc.eprint.version | Author's final manuscript | |
dc.type.uri | http://purl.org/eprint/type/SubmittedJournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Shivers, Robert P.; Kooistra, Tristan; Chu, Stephanie W.; Pagano, Daniel J.; Kim, Dennis H. | en |
dc.identifier.orcid | https://orcid.org/0000-0002-4109-5152 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |