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Second-order susceptibility imaging with polarization-resolved second harmonic generation microscopy

dc.contributor.authorSo, Peter T. C.
dc.contributor.authorChen, Wei-Liang
dc.contributor.authorLi, Tsung-Hsian
dc.contributor.authorSu, Ping-Jung
dc.contributor.authorChou, Chen-Kuan
dc.contributor.authorFwu, Peter Tramyeon
dc.contributor.authorDong, Chen-Yuan
dc.contributor.authorKim, Daekeun
dc.date.accessioned2010-09-17T14:17:30Z
dc.date.available2010-09-17T14:17:30Z
dc.date.issued2010-02
dc.date.submitted2010-01
dc.identifier.issn0277-786X
dc.identifier.urihttp://hdl.handle.net/1721.1/58582
dc.description.abstractSecond harmonic generation (SHG) microscopy has become an important tool for minimally invasive biomedical imaging. However, differentiation of different second harmonic generating species is mainly provided by morphological features. Using excitation polarization-resolved SHG microscopy we determined the ratios of the second-order susceptibility tensor elements at single pixel resolution. Mapping the resultant ratios for each pixel onto an image provides additional contrast for the differentiation of different sources of SHG. We demonstrate this technique by imaging collagen-muscle junction of chicken wing.en_US
dc.language.isoen_US
dc.publisherSPIEen_US
dc.relation.isversionofhttp://dx.doi.org/10.1117/12.843015en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSPIEen_US
dc.subjectsecond harmonic generationen_US
dc.subjectpolarizationen_US
dc.subjectmicroscopyen_US
dc.subjectcollagenen_US
dc.titleSecond-order susceptibility imaging with polarization-resolved second harmonic generation microscopyen_US
dc.typeArticleen_US
dc.identifier.citationWei-Liang Chen, Tsung-Hsian Li, Ping-Jung Su, Chen-Kuan Chou, Peter Tramyeon Fwu, Sung-Jan Lin, Daekeun Kim, Peter T. C. So, and Chen-Yuan Dong (2010). Second-order susceptibility imaging with polarization-resolved second harmonic generation microscopy. Proc. SPIE 7569, 75691P/1-7. ©2010 COPYRIGHT SPIE--The International Society for Optical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.approverSo, Peter T. C.
dc.contributor.mitauthorKim, Daekeun
dc.contributor.mitauthorSo, Peter T. C.
dc.relation.journalProceedings of SPIE--the International Society for Optical Engineering; v. 7569en_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChen, Wei-Liang; Li, Tsung-Hsian; Su, Ping-Jung; Chou, Chen-Kuan; Fwu, Peter Tramyeon; Lin, Sung-Jan; Kim, Daekeun; So, Peter T. C.; Dong, Chen-Yuanen
dc.identifier.orcidhttps://orcid.org/0000-0003-4698-6488
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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