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Molecular origin of strain softening in cross-linked F-actin networks

Author(s)
Ferrer, Jorge M.; Lang, Matthew J.; Kamm, Roger Dale; Lee, Hyungsuk
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Abstract
Two types of measurement are presented that relate molecular events to macroscopic behavior of F-actin networks. First, shear modulus is measured by oscillating an embedded microbead. Second, a microbead is translated at constant rate and transitions in the resisting force are observed. The loading rate dependence of the force at the transitions is similar to that of the molecular unbinding force, suggesting that they share a common origin. Reversibility tests of shear modulus provide further evidence that strain softening of F-actin networks is caused by force-induced rupture of cross-links.
Date issued
2010-07
URI
http://hdl.handle.net/1721.1/60906
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemistry; Massachusetts Institute of Technology. Department of Mechanical Engineering
Journal
Physical Review E
Publisher
American Physical Society
Citation
Lee, Hyungsuk et al. “Molecular origin of strain softening in cross-linked F-actin networks.” Physical Review E 82.1 (2010): 011919. © 2010 The American Physical Society.
Version: Final published version
ISSN
1539-3755
1550-2376

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